The Rowe lab studies acquisition and shedding, the first and last steps of a successful pathogen lifecycle, of bacterial and viral pathogens of the human upper respiratory tract. Using both bacterial (primarily Streptococcus pneumoniae) and viral (primarily Influenza A virus) pathogens of the human upper respiratory tract, the lab investigates how those pathogens interact with each other and with the members of the nasal microbiome in pathogenesis and transmission. Understanding these interactions can suggest why some people have uncomplicated influenza disease, while others end up hospitalized with secondary bacterial pneumonia, and why some people are more likely to transmit Influenza A virus than others. Other interests in the lab are to determine if other respiratory viruses likewise interact with respiratory bacteria in pathogenesis and transmission, and the role of co-infecting respiratory viruses on the transmission and invasive potential of opportunistic bacterial pathogens that colonize the human upper respiratory mucosa. Additionally, as Influenza A viruses also infect birds, an understanding of interactions of avian Influenza viruses with the avian microbiome could lend insights into the influenza transmission cycle in wild and domestic birds.
Ph.D. Wayne State University
B.S. Michigan State University
Research areasCellular Metabolism and Interaction Microbes, Microbiomes and Health Microbial Threats to Food Security
- Rajaei A, Rowe HM, Neely MN. 2022. The LCP Family Protein, Psr, Is Required for Cell Wall Integrity and Virulence in Streptococcus agalactiae. Microorganisms 2022, 10(2), 217; https://doi.org/10.3390/microorganisms10020217
- Matthews, A.J., Rowe, H.M., Rosch, J.W. and Camilli, A. 2021. A tri-seq screen of Streptococcus pneumoniae uncovers DNA repair as the major pathway for desiccation tolerance and transmission. Infection and Immunity 89(8) DOI:10.1128/IAI.00713-20.
- Rowe, H.M. and Rosch J.W. 2021. Polymicrobial interactions operative during pathogen transmission. mBio. 12:e01027-21. https://doi.org/10.1128/mBio.01027-21.
- Nashimoto, A., Wohlgemuth, N., Rosch, J.W., and Rowe, H.M. 2020. Transkingdom interactions important for the pathogenesis of human viruses. J. of Infectious Dis. 223(Supplement_3) DOI:10.1093/infdis/jiaa735.
- Rowe, H.M., Livingston, B., Margolis, E., Davis, A., Meliopoulos, V.A., Echlin, H., Schultz-Cherry, S., and Rosch, J.W. 2020. Respiratory Bacteria Stabilize and Promote Airborne Transmission of Influenza A Virus. mSystems. 5(5):e00762-20. doi: 10.1128/mSystems.00762-20. PMID:
- Cooper, V.S., Honsa, E., Rowe, H., Deitrick, C., Iverson, A.R., Whittall, J.J., Neville, S.L., McDevitt, C.A., Kietzman, C., and Rosch, J.W. 2020. Experimental Evolution In Vivo To Identify Selective Pressures during Pneumococcal Colonization. mSystems. 5(3):e00352-20. doi: 10.1128/mSystems.
- Cortez, V., Boyd, D.F., Crawford, J.C., Sharp, B., Livingston, B., Rowe, H.M., Davis, A., Alsallaq, R., Robinson, C.G., Vogel, P., Rosch, J.W., Margolis, E., Thomas, and P.G., Schultz-Cherry, S. 2020. Astrovirus infects actively secreting goblet cells and alters the gut mucus barrier. Nat. Commun. 11(1):2097.
- Rowe, H.M., Meliopoulos, V.A., Iverson, A., Bomme, P., Schultz-Cherry, S., and Rosch, J.W., 2019. Direct interactions with influenza promote bacterial adherence during respiratory infections. Nature Microbiology (8):1328-1336.
- Rowe, H.M., Karlsson, E., Echlin, H., Chang, T.C., Wang, L., van Opijnen, T., Pounds, S.B., Schultz-Cherry, S., and Rosch, J.W. 2019. Bacterial Factors Required for Transmission of Streptococcus pneumoniae in Mammalian Hosts. Cell Host Microbe. (6):884-891.
- Penkert, R.R., Rowe, H.M., Surman, S.L., Sealy, R.E., Rosch, J., Hurwitz, J.L. 2019. Influences of Vitamin A on Vaccine Immunogenicity and Efficacy. Front Immunol. 10:1576.
- Rowe, H.M., Mann, B., Iverson, A., Poole, A., Tuomanen, E., and Rosch, J.W. 2019. A Cross-Reactive Protein Vaccine Combined with PCV-13 Prevents Streptococcus pneumoniae- and Haemophilus influenzae-Mediated Acute Otitis Media. Infect. Immun. 87(10).
- Rowe, H.M. and Rosch J.W. 2019. Close Encounters of the Viral Kind: Cross-Kingdom Synergies at the Host-Pathogen Interface. Bioessays. (12):e1900128.
- Rowe, H.M. and Huntley, J.F. 2015. From the Outside-In: The Francisella tularensis Envelope and Virulence. Front Cell Infect. Microbiol. 5:94.
- Rowe, H.M., Hanson, B.R., Runft, D.L., Lin, Q., Firestine, S.M. and Neely, M.N. 2015. Modification of the CpsA protein reveals a role in alteration of the Streptococcus agalactiae cell envelope. Infect Immun. 83(4):1497-506.
- Namprachan-Frantz, P., Rowe, H.M., Runft, D.L., and Neely, M.N. 2014. Transcriptional analysis of the Streptococcus pyogenes salivaricin locus. J Bacteriol. 196(3):604-13.
- Rowe, H.M., Withey, J.H., and Neely, M.N. 2014. Zebrafish as a model for zoonotic aquatic pathogens. Dev. Comp. Immunol. 46(1):96-107.