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Dr. Malcolm Lowry, Assistant Professor
|Office:||453 Linus Pauling Science Center
|Education:||PhD Molecular Genetics, Ohio State University|
RESEARCH INTERESTS: Innate immune cells that provide protection against infection
COURSES TAUGHT: MB 416/516 Medical Immunology; MB 417/517 Medical Immunology Laboratory; MB 699 Special Topics in Immunology
I have worked mainly on projects focused on the role of innate immune cells in providing protection against infections. My areas of expertise are on macrophage cells and their functions including phagocytosis and how they sense pathogens by Toll-like receptors. My current work is in collaboration with Dr. Fritz Gombart studying anti-microbial peptides produced by immune system cells. The particular antimicrobial peptide we focus on is cathelicidin which is unique in that it is regulated by Vitamin D. We use both human cells and mouse models to understand the roles of Vitamin D and cathelicidin in immune system functions.
Publications of Interest:
M. B. Lowry, A. M. Duchemin, J. M. Robinson, and C. L. Anderson. 1998. Functional separation of pseudopod extension and particle internalization during Fcg Receptor-mediated phagocytosis. J. Exp. Med. 187:161-176.
M. B. Lowry, A. M. Duchemin, K. M. Coggeshall, J. M. Robinson, and C. L. Anderson 1998. Chimeric receptors composed of PI3-Kinase domains and Fcg Receptor ligand binding domains mediate phagocytosis in COS fibroblasts. J. Biol. Chem. 273: 24513-20.
Fitzer-Attas, C.J., M. Lowry, M.T. Crowley, A.J. Finn, F. Meng, A.L. DeFranco, and C.A. Lowell 2000. Fcg receptor-mediated phagocytosis in macrophages lacking the Src-family tyrosine kinases Hck, Fgr, and Lyn. J Exp Med. 191(4):669-82.
Lowry MB, Lotinun S, Leontovich AA, Zhang M, Maran A, Shogren KL, Palama BK, Marley K, Iwaniec UT, Turner RT 2008. Osteitis Fibrosa is Mediated by PDGF-A via a PI3K-dependent Signaling Pathway in a Rat Model for Chronic Hyperparathyroidism. Endocrinology. Nov;149(11):5735-46.
Menagh PJ, Turner RT, Jump DB, Wong CP, Lowry MB, Yakar S, Rosen CJ, Iwaniec UT. 2010 Growth hormone regulates the balance between bone formation and bone marrow adiposity. J Bone Miner Res. 2010 Apr;25(4):757-68.
Guo C, Rosoha E, Lowry MB, Borregaard N, Gombart AF. 2013 . Curcumin induces human cathelicidin antimicrobial peptide gene expression through a vitamin D receptor-independent pathway. J Nutr Biochem. 2013 May;24(5):754-9.
Guo C, Sinnott B, Niu B, Lowry MB, Fantacone ML, Gombart AF. 2013. Synergistic induction of human cathelicidin antimicrobial peptide gene expression by vitamin D and stilbenoids. Mol Nutr Food Res. 2013 Sep 14.
Microscopy of a macrophage (green) phagocytosing apoptotic cells (red circles).